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Peptide bonds are susceptible to cleavage in the presence of water, particularly at elevated temperatures

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Researchers observed that BPC-157 is associated with upregulation of growth factor receptor expression, including VEGFR2 and FGFR, which may contribute to its studied effects on angiogenesis

In vascular experiments, nitric oxide related signaling also appears to play a central role, linking BPC-157 activity to endothelial nitric oxide synthase regulation and nitric oxide dependent cellular signaling [7]